منابع مشابه
Comorbid pain and migraine chronicity
OBJECTIVE To identify patterns of noncephalic pain comorbidity in people with episodic migraine (EM; <15 headache-days per month) and chronic migraine (CM; ≥15 headache-days per month) and to examine whether the presence of noncephalic pain is an indicator for the 3-month onset or persistence of CM. METHODS Data from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study, a prospective,...
متن کاملSubstance P and Acute Pain in Patients Undergoing Orthopedic Surgery
OBJECTIVE There is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to find the correlation between SP level changes and acute pain intensity in patients with rheumatoid ...
متن کاملSubstance p and pain in orthodontics: A brief review
These neurotransmitters are capable to act on specific receptors expressed in nociceptive sensory neuron thus resulting in the production of second messengers and eventually activating the downstream pathway of protein kinase and phospholipases . Peripheral nociceptors are detectors of specific biochemical compounds and are also constituted by ion channels. Both type of receptors are involved i...
متن کاملPeripheral Mechanisms of Dental Pain: The Role of Substance P
Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes. The major role of substance P in the onset of dental pain and infla...
متن کاملSubstance P as a potential biomarker of pain assessment in dogs
Background: Substance P (SP) is a neuropeptide that functions as a neuromodulator. It is released mainly in the brain stem and in nerve endings. Aims: The present study aimed to provide fundamental data that may be applied to the assessment of pain in dogs by evaluating their serum SP concentrations. Methods: Two groups of dogs were designated ...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2018
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-018-2922-y